Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: Orally active prostacyclin mimetics. Part 2

…, S Tabuchi, K Taniguchi, M Nishio, S Koyama…

Index: Hattori, Kouji; Okitsu, Osamu; Tabuchi, Seiichiro; Taniguchi, Kiyoshi; Nishio, Mie; Koyama, Satoshi; Seki, Jiro; Sakane, Kazuo Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 13 p. 3279 - 3283

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Citation Number: 9

Abstract

Synthetic and biological evaluation of novel diphenyloxazole derivatives containing a pyrrolidine ring, as a prostacyclin mimetic without the PG skeleton, are described. Asymmetric reduction of a ketone using a chiral Ru complex and reductive amination by NaBH4 produces four isomers of the tetrahydronaphthalene ring and the pyrrolidine ring with high stereoselectivity. FR193262 (4),(R, R)-diphenyloxazolyl pyrrolidine derivative, ...