Crystallisation induced asymmetric transformation (CIAT) in the synthesis of furoylalanines and furylcarbinols

P Jakubec, D Berkeš, R Šiška, M Gardianová…

Index: Jakubec, Pavol; Berkes, Dusan; Siska, Richard; Gardianova, Maria; Povazanec, Frantisek Tetrahedron Asymmetry, 2006 , vol. 17, # 11 p. 1629 - 1637

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Citation Number: 20

Abstract

A new synthesis of enantiomerically highly enriched N-substituted furoylalanines has been developed. This process involves the combination of crystallisation induced asymmetric transformation (CIAT) and a conjugate addition of N-nucleophiles to furoylacrylic acids. Further transformations to furoylalanines and substituted furylcarbinols are also described.

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