Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-α

…, MS Morales-Ríos, E Hernández-Gallegos…

Index: Rivera-Guevara, Claudia; Perez-Alvarez, Victor; Garcia-Becerra, Rocio; Ordaz-Rosado, David; Morales-Rios, Martha Sonia; Hernandez-Gallegos, Elizabeth; Cooney, Austin J.; Bravo-Gomez, Maria Elena; Larrea, Fernando; Camacho, Javier Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5593 - 5601

Full Text: HTML

Citation Number: 7

Abstract

Tamoxifen is a selective estrogen receptor modulator widely used in oncology and reproductive endocrinology. In order to decrease its non-desirable effects and elucidate mechanisms of action, permanently charged tamoxifen derivatives (PCTDs) have been reported. Whether PCTDs have genomic effects remains controversial. Since the clinical relevance of tamoxifen, the necessity to have new anticancer drugs, and in order to gain ...