Novel, potent aldose reductase inhibitors: 3, 4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners

BL Mylari, ER Larson, TA Beyer…

Index: Journal of Medicinal Chemistry, , vol. 34, # 1 p. 108 - 122

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Citation Number: 198

Abstract

... ARIs strongly suggest that diabetic complications could be a consequence of increased flux through the poly01 pathway and/or high intracellular accumulation of sorbitoL2 Spurred by this, several pharmaceutical companies are ... Journal of Medicinal Chemistry, 1991, Vol. ...