Potential antisecretory antidiarrheals. 1.. alpha. 2-Adrenergic aromatic aminoguanidine hydrazones

…, RG Bianchi, P Palicharla, EL Sanguinetti…

Index: Pitzele; Moormann; Gullikson; Albin; Bianchi; Palicharla; Sanguinetti; Walters Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 138 - 144

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Citation Number: 11

Abstract

Guanabenz, a centrally acting antihypertensive agent, has been shown to have intestinal antisecretory properties. A series of aromatic aminoguanidine hydrazones was made in an effort to separate the antisecretory and cardiovascular activities. Benzaldehyde, naphthaldehyde, and tetralone derivatives were synthesized. The compounds were evaluated in the cholera toxin treated ligated jejunum of the rat and in the Ussing chamber ...