Enhanced enantioselectivity of Bacillus coagulans in the hydrolysis of 1, 2-O-isopropylidene glycerol esters by thermal knock-out of undesired enzymes

…, F Molinari, A Buthe, M Ansorge-Schumacher

Index: Romano, Diego; Falcioni, Francesco; Mora, Diego; Molinari, Francesco; Buthe, Andreas; Ansorge-Schumacher, Marion Tetrahedron Asymmetry, 2005 , vol. 16, # 4 p. 841 - 845

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Citation Number: 19

Abstract

The enantioselective hydrolysis of different (RS)-1, 2-O-isopropylidene glycerol esters has been achieved with whole cells of Bacillus coagulans NCIMB 9365 furnishing the (S)- alcohol as the major enantiomer. The reaction is catalysed by a thermostable cell-bound carboxylesterase and improvement of the enantioselectivity has been achieved by heat treatment of the whole cells, which causes the knock-outs a non-enantioselective ...

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