Azido/Tetrazole Tautomerism in 2??Azidoadenine β??D??Pentofuranonucleoside Derivatives

T Lioux, G Gosselin, C Mathé

Index: Lioux, Thierry; Gosselin, Gilles; Mathe, Christophe European Journal of Organic Chemistry, 2003 , # 20 p. 3997 - 4002

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Citation Number: 24

Abstract

Abstract The β-D-ribofuranoside derivative of 2-azidoadenine and its 2′-deoxy-, 2′, 3′- dideoxy-and 2′, 3′-dideoxy-2′, 3′-didehydro counterparts have been synthesized. All these compounds were obtained through the preparation of their 2-chloro precursors. These were converted into their 2-hydrazino derivatives, which upon treatment with sodium nitrate in acid medium gave the target nucleosides. The azido/tetrazole tautomerism observed in ...

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