Synlett

Palladium-mediated highly regio-and stereoselective intermolecular β-arylation on allylic alcohols: Synthesis of functionalized allylic alcohols

J Krishna, AGK Reddy, BV Ramulu, L Mahendar…

Index: Krishna; Reddy, A. Gopi Krishna; Ramulu, B. Venkat; Mahendar; Satyanarayana Synlett, 2012 , # 3 p. 375 - 380

Full Text: HTML

Citation Number: 14

Abstract

Abstract An efficient and highly regio-and stereoselctive Pd-catalyzed β-arylation method for the formation of β-aryl allylic alcohols, employing aryl iodides, 1-bromo-2-iodobenzenes, and 2-bromobezaldehydes as coupling partners, is presented. The β-aryl allylic alcohols formed in this Pd-catalyzed transformation is unexpected under conventional Jeffery conditions without the assistance of silver salt. It is proposed that the reaction is substrate ...