Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1, 1??Difluoro??1??alkenes

GK Prakash, J Hu, Y Wang…

Index: Prakash, G.K. Surya; Hu, Jinbo; Wang, Ying; Olah, George A. Angewandte Chemie - International Edition, 2004 , vol. 43, # 39 p. 5203 - 5206

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Citation Number: 61

Abstract

1, 1-Difluoro-1-alkenes are unique compounds with unusually high electrophilicity from the gem-difluorovinyl group, and recently have drawn many synthetic and theoretical endeavors.[1] gem-Difluorovinyl functionality has been known to act as a bioisostere for aldehydes and ketones,[2] and it is critical to many biologically active molecules such as enzyme inhibitors [1, 3] and pesticides.[4] 1, 1-Difluoro-1-alkenes are also useful synthetic ...