Orthogonal Protecting Groups in the Synthesis of Tryptophanyl??Hexahydropyrroloindoles

P Ruiz??Sanchis, SA Savina, GA Acosta…

Index: Ruiz-Sanchis, Pau; Savina, Svetlana A.; Acosta, Gerardo A.; Albericio, Fernando; Alvarez, Mercedes European Journal of Organic Chemistry, 2012 , # 1 p. 67 - 73

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Citation Number: 2

Abstract

Abstract The synthesis of various polycyclic systems containing aC 3a–N i bond between a hexahydropyrrolo [2, 3-b] indole and an indole tryptophan is described here. A series of experiments were performed to determine the best combination of five orthogonal protecting groups and the best reaction conditions for formation of said bond, which is a common feature among many recently discovered marine natural products.