Alkylating Agents Related to 2, 2'-Biaziridine. II. 1 N, N'-Dicarbethoxy-2, 2'-biaziridine

PW Feit, OT Nielsen

Index: Feit,P.W.; Nielsen,O.T. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 927 - 932

Full Text: HTML

Citation Number: 9

Abstract

For the S, X'-dicarbethoxydiamiriobutanediol bismethanesulforiates 1 and 2 a ring closure to the biaziridine 3 seems unlikely urider physiological pH as this reaction proceeds in vit7. o urider strong alkaline conditions only. However, there might be a possibility of metabolizing to the urisubstituted amino compounds which are considered in vivo precursors of the corresponding 2, 2'-biaziridine, Chemistry.-The synthetic route for the preparatiuii of DL-1 ...