Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy
WY Shao, YN Cao, ZW Yu, WJ Pan, X Qiu, XZ Bu…
Index: Shao, Wei-Yan; Cao, Ying-Nan; Yu, Zhi-Wen; Pan, Wen-Jie; Qiu, Xu; Bu, Xian-Zhang; An, Lin-Kun; Huang, Zhi-Shu; Gu, Lian-Quan; Chan, Albert S.C. Tetrahedron Letters, 2006 , vol. 47, # 24 p. 4085 - 4089
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Citation Number: 30
Abstract
Curcumin, a yellow pigment isolated from the root of Curcuma longa rhizomes, was widely used as food additive for many years. It has been found in the last decades that curcumin derivatives possess broad biological activities, such as antioxidant activity, 1 anti-imflammatory properties, 2 anti-HIV protease activity 3 and cancer preventive properties. 4 and 5 Although the poor solubility becomes a major problem in pharmacological test, a large number of ...