New neplanocin analogs. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents

…, M Toriya, M Hosoya, R Snoeck, G Andrei…

Index: Shuto; Obara; Toriya; Hosoya; Snoeck; Andrei; Balzarini; De Clercq Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 324 - 331

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Citation Number: 85

Abstract

Novel neplanociu A analogues modified at the 6'-pition, ie, 6'-deoxy analogues (2, 3, 6, 9, 20), 6'-0-methylneplan& A (15), and 6 '-C-methylneplanocin A's (22a and 22b) have been synthesized and evaluated for their antiviral activity in a wide variety of DNA and RNA virus systems. These compounds showed an activity spectrum that conforms to that of S- adenoeylhomocyateine hydrolase inhibitors. They were particularly active against pox-( ...