4??aminoquinoline??triazine??based hybrids with improved in vitro antimalarial activity against cq??sensitive and cq??resistant strains of plasmodium falciparum

S Manohar, SI Khan, DS Rawat

Index: Manohar, Sunny; Khan, Shabana I.; Rawat, Diwan S. Chemical Biology and Drug Design, 2013 , vol. 81, # 5 p. 625 - 630

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Citation Number: 30

Abstract

A systematic chemical modification in the triazine moiety covalently attached via suitable linkers to 4-amino-7-chloroquinolines yielded a series of new 7-chloro-4-aminoquinoline- triazine hybrids exhibiting high in vitro activity against W2 (chloroquine-resistant) and D6 (chloroquine-sensitive) strains of Plasmodium falciparum without any toxicity against mammalian cell lines (Vero, LLC-PK11, HepG2). Many of the compounds (6, 8, 10, 11, 13, ...