Affinity of 1-aryl-1, 2, 3, 4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex
M Ludwig, CE Hoesl, G Höfner, KT Wanner
Index: Ludwig, Matthias; Hoesl, Cornelia E.; Hoefner, Georg; Wanner, Klaus T. European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 1003 - 1010
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Citation Number: 36
Abstract
A series of 1-aryl-1, 2, 3, 4-tetrahydroisoquinoline and 8-methyl-1-aryl-1, 2, 3, 4- tetrahydroisoquinoline derivatives was evaluated for affinity to the PCP binding site of the NMDA receptor complex. The (S)-configurated tetrahydroisoquinoline derivative (S)-4e· HCl bearing a 2-methylphenyl substituent in position 1 of the heterocyclic ring system and a methyl group in position 8 was found to exhibit the highest affinity among the derivatives ...
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