Synthesis of [2??{(4??chlorophenyl)(4??[125I] iodophenyl)} methoxyethyl]??1??piperidine??3??carboxylic acid,[125I] CIPCA: A potential radiotracer for GABA uptake sites

ME Van Dort, DL Gildersleeve…

Index: Van Dort; Gildersleeve; Wieland Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 10 p. 961 - 971

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Citation Number: 3

Abstract

Abstract The synthesis of racemic [2-{(4-Chlorophenyl)(4-iodophenyl)} methoxyethyl]-1- piperidine-3-carboxylic acid,(CIPCA) and its radioiodinated analog [125ß I] CIPCA is described. CIPCA was synthesized from 4-iodobenzoyl chloride in five steps in 16% overall yield. Ammonium sulfate catalyzed solid-state isotopic exchange of CIPCA with Na 125 I provided [125 I] CIPCA in 34% isolated radiochemical yield at a specific activity of 118 Ci/ ...