Semisynthesis of Flexible 5, 7??Dideoxypaclitaxel Derivatives from Taxine B
…, H Veldhuis, BAC van den Bossche…
Index: Beusker, Patrick H.; Veldhuis, Harald; Van Den Bossche, Bianca A. C.; Scheeren, Hans W. European Journal of Organic Chemistry, 2001 , # 9 p. 1761 - 1768
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Abstract
Abstract Two new 5, 7-dideoxypaclitaxel derivatives with flexible C-rings have been prepared starting from Taxine B, an alkaloid isolated from the leaves of Taxus baccata. Both derivatives lack the oxetane ring present in the antitumor agent paclitaxel, but possess an oxygenated 4β-substituent as a substitute for the oxetane ring oxygen atom. These derivatives provide additional information about the importance of this oxygen atom for ...
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