Enantiocontrolled Synthesis of 2, 3, 6-Trisubstituted Piperidines Using (η3-Dihydropyridinyl) molybdenum Complexes as Chiral Scaffolds. Total Synthesis of (-)- …

…, A Alcudia, J Yin, LS Liebeskind

Index: Shu; Alcudia; Yin; Liebeskind Journal of the American Chemical Society, 2001 , vol. 123, # 50 p. 12477 - 12487

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Citation Number: 46

Abstract

Enantiopure TpMo (CO) 2 (pyridinyl) complexes were prepared using an efficient and scalable enzymatic kinetic resolution of the precursor to the molybdenum complex. A single TpMo (CO) 2 (pyridinyl) complex can function as a chiral scaffold for the enantiocontrolled synthesis of either 2, 3, 6-cis-or 2, 6-cis-3-trans-trisubstituted piperidines. The synthetic potential of this methodology was demonstrated by a total synthesis of (-)-indolizidine ...