Synlett

Highly regioselective Heck coupling reactions of aryl halides and dihydropyran in the presence of an NHC-pyridine ligand

J Jarusiewicz, KS Yoo, KW Jung

Index: Jarusiewicz, Jamiei; Kyung, Soo Yoo; Kyung, Woon Jung Synlett, 2009 , # 3 p. 482 - 486

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Citation Number: 10

Abstract

Abstract The Heck coupling reactions of aryl halides and 3, 4-dihydro-2H-pyran facilitated the regioselective synthesis of arylated cyclic enol ethers. Good yields were obtained using 5 mol% of an NHC-ligand-Pd-catalyst complex in the presence of K 2 CO 3 in DMF at 100 C. The use of this catalytic system broadens the substrate scope and improves the selectivity for this cross-coupling process.

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