Synthesis, NMR spectroscopy study, and antimuscarinic activity of a series of 2-(acyloxymethyl)-1, 3-dioxolanes

L Malmusi, A Mucci, L Schenetti, U Gulini…

Index: Malmusi, Luca; Mucci, Adele; Schenetti, Luisa; Gulini, Ugo; Marucci, Gabriella; Brasili, Livio Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2071 - 2080

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Citation Number: 10

Abstract

A series of 1, 3-dioxolane-based ligands, bearing hydroxymethyl or ester functionalities, was synthesized and tested as potential muscarinic antagonists. The compounds display moderate to low affinity for the three receptor subtypes M1-M3, with some of them showing a significant selectivity for the M3 subtype. The configurational and conformational properties were studied using NOE experiments and vicinal coupling constants. The 1H and 13C ...

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