Intramolecular reductive ketone–alkynoate coupling reaction promoted by (η 2-propene) titanium

C Schaefer, M Miesch, L Miesch

Index: Schaefer, Christian; Miesch, Michel; Miesch, Laurence Organic and Biomolecular Chemistry, 2012 , vol. 10, # 16 p. 3253 - 3257

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Citation Number: 6

Abstract

Intramolecular reductive coupling of cycloalkanones tethered to alkynoates in the presence of (η2-propene) titanium was successfully performed to provide hydroxy-esters in a diastereoselective manner. Subsequent lactonization afforded angularly fused unsaturated tricyclic lactones which represent relevant substructures of numerous bioactive compounds.