Tetrahedron letters

Enzyme-catalyzed asymmetrization of 2, 2-disubstituted 1, 3-propanediols using 1-ethoxyvinyl esters

S Akai, T Naka, Y Takebe, Y Kita

Index: Akai, Shuji; Naka, Tadaatsu; Takebe, Yasushi; Kita, Yasuyuki Tetrahedron Letters, 1997 , vol. 38, # 24 p. 4243 - 4246

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Citation Number: 23

Abstract

The lipase-catalyzed asymmetrization of the prochiral 2, 2-disubstituted 1, 3-propanediols 1, 6, and 9 was studied using various types of 1-ethoxyvinyl esters 2. Among them, the use of the benzoate 2f provided good chemical and optical yields of the products 3, 7, and 10 bearing chiral quaternary carbon centers which are fairly stable against racemization.