Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols: An efficient access to homoallylic alcohols with a chiral quaternary center

Q Zhang, SF Zhu, Y Cai, LX Wang, QL Zhou

Index: Zhang, Qi; Zhu, Shou-Fei; Cai, Yan; Wang, Li-Xin; Zhou, Qi-Lin Science China Chemistry, 2010 , vol. 53, # 9 p. 1899 - 1906

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Abstract

Abstract Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed. A series of homoallylic alcohols with a chiral quaternary center were produced in high yields (up to 97%) and high enantioselectivities (up to 95% ee). The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.