Tetrahedron letters

Reductive decyanation of pyrazinecarbonitriles

J Albaneze-Walker, M Zhao, MD Baker, PG Dormer…

Index: Albaneze-Walker, Jennifer; Zhao, Matthew; Baker, Melinda D; Dormer, Peter G; McNamara, James Tetrahedron Letters, 2002 , vol. 43, # 38 p. 6747 - 6750

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Citation Number: 10

Abstract

Pyrazinecarbonitriles can be decyanated by hydrogenation with platinum on carbon in the presence of activated carbon under acidic conditions. Pyrazine carbonitrile-N-oxides undergo a stepwise reduction to the deoxy-pyrazinecarbonitriles followed by decyanation to give pyrazines in good yields.

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Reductive decyanation of pyrazinecarbonitriles

[Tetrahedron Letters, , vol. 43, # 38 p. 6747 - 6750]

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