Organic letters

An Efficient Synthesis of the Fully Elaborated Isoindolinone Unit of Muironolide A

Q Xiao, K Young, A Zakarian

Index: Xiao, Qing; Young, Kyle; Zakarian, Armen Organic Letters, 2013 , vol. 15, # 13 p. 3314 - 3317

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Citation Number: 12

Abstract

An efficient stereocontrolled construction of the fully substituted isoindolone subunit of muironolide A is described. The approach is centered on the intramolecular Diels–Alder reaction between the enol form of the β-keto amide and an α, β, γ, δ-unsaturated ester, followed by the installation of the cyclohexene double bond.

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