Concise synthesis and structure–activity relationship of furospinosulin-1, a hypoxia-selective growth inhibitor from marine sponge

…, M Yamada, Y Sumii, T Kawachi, M Arai, M Kobayashi

Index: Kotoku, Naoyuki; Fujioka, Shinichi; Nakata, Chiaki; Yamada, Masaki; Sumii, Yuji; Kawachi, Takashi; Arai, Masayoshi; Kobayashi, Motomasa Tetrahedron, 2011 , vol. 67, # 35 p. 6673 - 6678

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Citation Number: 16

Abstract

Structure–activity relationship of furospinosulin-1 (1), a hypoxia-selective growth inhibitor isolated from marine sponge, was investigated. Concise synthetic method of 1 was developed, and some structurally modified analogues were prepared. Biological evaluation of them revealed that the whole chemical structure was important for the hypoxia-selective growth inhibitory activity of 1. Among prepared, the desmethyl analogue 30 showed ...