Synthetic communications

One pot hydroformylation/intramolecular aldol condensation reactions of 1-allyl-2-carbonylpyrroles: a new entry into hydroindolizines synthesis

R Settambolo, S Miniati, R Lazzaroni

Index: Settambolo, Roberta; Miniati, Sandra; Lazzaroni, Raffaello Synthetic Communications, 2003 , vol. 33, # 17 p. 2953 - 2961

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Citation Number: 19

Abstract

Abstract 7-Formyl-5-methyl-5, 6-dihydroindolizine and 7-formyl-6-methyl-5, 6- dihydroindolizine were obtained via a domino hydroformylation/cyclization/dehydration reactions sequence starting from the corresponding 1-allyl-2-formylpyrroles. An intramolecular aldol condensation between the carbon atom adjacent to the formyl group in the chain of the produced aldehydes and the carbonyl group directly bonded to the pyrrole ...