Molecules

Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum

WL Wang, LJ Song, X Chen, XR Yin, WH Fan…

Index: Molecules, , vol. 18, # 8 p. 9163 - 9178

Full Text: HTML

Citation Number: 4

Abstract

... Volume. Page. ... Molecules 2013, 18(8), 9163-9178; doi:10.3390/molecules18089163. ... There are five positions amenable for chemical modification in the PZQ molecular structure [16,22] (Figure 1). Among these, only position R 1 has been heavily investigated [21]. ...

New syntheses of praziquantel: 2-(cyclohexylcarbonyl)-1, 2, 3, 6, 7, 11b-hexahy-dro-4H-pyrazino [2, 1-a] isoquinolin-4-one

[Heterocycles, , vol. 20, # 9 p. 1731 - 1735]

Synthesis of praziquantel via N-acyliminium ion cyclization of amido acetals through several synthetic routes

[Heterocycles, , vol. 48, # 11 p. 2279 - 2285]

Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals

[Journal of Organic Chemistry, , vol. 67, # 12 p. 3985 - 3988]