Synlett

2-Bromo-N-(p-toluenesulfonyl) pyrrole: A Robust Derivative of 2-Bromopyrrole

LW Knight, JW Huffman, ML Isherwood

Index: Knight, Lea W.; Huffman, John W.; Isherwood, Matthew L. Synlett, 2003 , # 13 p. 1993 - 1996

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Abstract

Abstract 2-Bromo-N-(p-toluenesulfonyl) pyrrole (2), a crystalline stable derivative of 2- bromopyrrole (1) has been prepared in 80% yield by bromination of pyrrole, followed by conversion to the N-(p-toluenesulfonyl) derivative. This compound is stable indefinitely at ambient temperature. Compound 2 is an excellent substrate for Suzuki coupling with arylboronic acids.