SOLVENT-FREE SYNTHESIS OF SPIRO [3 H-INDOLE-3, 2′-THIAZOLIDINES]

A Dandia, R Singh, K Arya

Index: Dandia, Anshu; Singh, Ruby; Arya, Kapil Organic Preparations and Procedures International, 2003 , vol. 35, # 4 p. 401 - 408

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Citation Number: 12

Abstract

Thiazolidinones14 and spir~[indole-thiazoliidines]~-~ have attracted considerable attention because of their wide biological and pharmacological activities. The spiro [indole-thiazolidi- none] system has been synthesized earlier by a two-step procedure in 40-60% yield using isatin-3-imines as key intermediates, themselves obtained hm substituted isatins and aromatic amines. The classical method involves either the azeotropic removal of water9Jo ...