Synthesis and 11C??labelling of (E, E)??1??(3′, 4′??dihydroxystyryl)??4??(3′??methoxy??4′??hydroxystyryl) benzene for PET imaging of amyloid deposits†

Y Wang, CA Mathis, G Huang, DP Holt…

Index: Wang, Yanming; Mathis, Chester A.; Huang, Guo-Feng; Holt, Daniel P.; Debnath, Manik L.; Klunk, William E. Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 8 p. 647 - 664

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Citation Number: 27

Abstract

Abstract Carboxylic acid derivatives of the amyloid-binding dye Congo red do not enter the brain well and are thus unable to serve as in vivo amyloid-imaging agents. A neutral amyloid probe,(E, E)-1-(3′, 4′-dihydroxystyryl)-4-(3′-methoxy-4′-hydroxystyryl) benzene (3), devoid of any carboxylate groups has been designed and synthesized via a 12-step reaction sequence with a total yield of 30%. The unsymmetric compound 3 has also been labelled ...