Synthesis and pharmacological studies of some aliphatic hemicholinium analogs

MF Powers, S Kruger…

Index: Powers,M.F. et al. Journal of Pharmaceutical Sciences, 1962 , vol. 51, # 1 p. 27 - 31

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Citation Number: 8

Abstract

Abstract The aromatic nucleus of hemicholinium-3 was replaced with an aliphatic hexa- methylene chain without loss of the characteristic pharmacological activity. The toxic dose was elevated in mice about tenfold by the change. Choline chloride was a very effective antidote to intoxication from the aliphatic hemicholinium. Another compound synthesized, a pyridine analog, had marked anticholinesterase activity, but caused a flaccid paralysis in ...