Garcinia xanthones as orally active antitumor agents
…, X Liu, S Zhang, Y Wang, Y Yang, S Zeng…
Index: Zhang, Xiaojin; Li, Xiang; Sun, Haopeng; Wang, Xiaojian; Zhao, Li; Gao, Yuan; Liu, Xiaorong; Zhang, Shenglie; Wang, Yanyan; Yang, Yingrui; Zeng, Su; Guo, Qinglong; You, Qidong Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 276 - 292
Full Text: HTML
Citation Number: 29
Abstract
Using a newly developed strategy whose key step is the regioselective propargylation of hydroxyxanthone substrates, 99 structurally diverse Garcinia natural-product-like xanthones based on gambogic acid were designed and synthesized and their in vitro antitumor activity was evaluated. A set of 40 related compounds was chosen for determination of their physicochemical properties including polar surface area, log D 7.4, aqueous solubility, ...
Related Articles:
[Sun, Haopeng; Chen, Feihong; Wang, Xiaojian; Liu, Zongliang; Yang, Qian; Zhang, Xiaojin; Zhu, Jia; Qiang, Lei; Guo, Qinglong; You, Qidong European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 110 - 123]
[Tisdale, Eric J.; Slobodov, Irina; Theodorakis, Emmanuel A. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 24 p. 4418 - 4422]
[Tisdale, Eric J.; Slobodov, Irina; Theodorakis, Emmanuel A. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 24 p. 4418 - 4422]
[Tisdale, Eric J.; Slobodov, Irina; Theodorakis, Emmanuel A. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 24 p. 4418 - 4422]