Enantioselective synthesis of polyfunctional small building blocks with a quaternary stereogenic center
D Enders, A Zamponi, T Schäfer, C Nübling…
Index: Enders, Dieter; Zamponi, Andreas; Schaefer, Thomas; Nuebling, Christoph; Eichenauer, Herbert; et al. Chemische Berichte, 1994 , vol. 127, # 9 p. 1707 - 1722
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Citation Number: 18
Abstract
Abstract Application of the SAMP-/RAMP-hydrazone method offers an efficient and flexible access to compounds with a quaternary stereogenic center. Examples bearing silyl, thio, phenyl, aldo, keto, ester, and alkyl functionalities are described. The 2-phenylaldehydes and- ketones and the β-keto esters 4 were obtained in good overall yields and with variable enantiomeric excesses. The synthesis of the thiolated 2-formyl and 3-formyl carboxylic ...
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