Angucycline C5 glycosides: regio-and stereocontrolled synthesis and cytotoxicity

P Mitra, B Behera, TK Maiti, D Mal

Index: Mitra, Prithiba; Behera, Birendra; Maiti, Tapas K.; Mal, Dipakranjan Journal of Organic Chemistry, 2013 , vol. 78, # 19 p. 9748 - 9757

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Citation Number: 4

Abstract

This study discloses a general and convergent route for the regio-and stereospecific construction of the C5 glycosyl angucycline framework of mayamycin. C-Glycosidation, dearomatization, and Hauser annulation are the key steps. The synthetic analogues show cytotoxicity against different human cancer cell lines with IC50 values between 16.4 and 1.2 μM.