Il Farmaco

2-(4-R-Phenoxy/phenylthio) alkanoic esters of l-lupinine

A Sparatore, F Sparatore

Index: Sparatore, Anna; Sparatore, Fabio Farmaco, 2001 , vol. 56, # 3 p. 169 - 174

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Citation Number: 2

Abstract

Considering the great pharmacological interest in phenoxy/phenylthioalkanoic esters of open-chain or cyclic aminoalcohols, a set of ten such esters of lupinine was prepared. Initially, their ability to displace [3H] QNB from rat brain preparation was investigated. With the exception of two, all the prepared esters exhibited good affinity to muscarinic receptors (on a non-selective basis), with pKi in the range 6.67–7.68.