Facile Synthesis of Bicyclo Orthoesters and Bicyclo Amide Acetals Using α, α-Difluoroalkylamines

S Tange, T Fukuhara, S Hara

Index: Tange, Seiko; Fukuhara, Tsuyoshi; Hara, Shoji Synthesis, 2008 , # 20 p. 3219 - 3222

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Citation Number: 2

Abstract

Abstract Bicyclo orthoesters and amide acetals were prepared from the corresponding triols or diethanolamines using α, α-difluoroalkylamines. The reaction proceeded under milder conditions than conventional methods. 4-tert-Butyl-1-(4-ethynylphenyl) trioxabicyclo [2.2. 2] octane, a new class of insecticide, was prepared from a triol in three steps using a difluoroalkylamine.