Tetrahedron

New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond

M Mori, N Kanda, I Oda, Y Ban

Index: Mori, Miwako; Kanda, Nana; Oda, Izumi; Ban, Yoshio Tetrahedron, 1985 , vol. 41, # 23 p. 5465 - 5474

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Citation Number: 78

Abstract

α-Haloamide having internal double bond was allowed to react with a catalytic amount of Pd (PPh3) 4 in the presence of base to produce a cyclized product in a fairly good yield possibly through the intermediate of-alkylmetal complex. By use of this method, five and six membered lactams, pyrrolizidine and quinolizidine derivatives were synthesized in fairly good yields.

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