A polymer-assisted solution-phase strategy for the synthesis of fused [2, 1-b] quinazolinones and the preparation of optically active vasicinone

A Kamal, V Devaiah, N Shankaraiah, KL Reddy

Index: Kamal, Ahmed; Devaiah; Shankaraiah; Laxma Reddy Synlett, 2006 , # 16 p. 2609 - 2612

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Citation Number: 14

Abstract

Abstract An efficient preparation of fused [2, 1-b] quinazolinones has been developed utilizing polymer-supported reagents.(±)-Vasicinone was converted into its dione by oxidation with poly (4-vinylpyridiniumdichromate). An efficient method has been developed for the synthesis of (d)-and (l)-vasicinone via asymmetric reduction of pyrrolo [2, 1-b] quinazoline-3, 9-dione by employing NaBH 4/Me 3 SiCl as the reducing agent and ...