Lipase-catalyzed resolution of chiral 2-amino 1-alcohols

F Francalanci, P Cesti, W Cabri, D Bianchi…

Index: Francalanci, Franco; Cesti, Pietro; Cabri, Walter; Bianchi, Daniele; Martinengo, Tiziano; Foa, Marco Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5079 - 5082

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Citation Number: 76

Abstract

Results Lipase-Catalyzed Hydrolysis of 2-[N-(Alkoxycarbonyl) amino] 1-Alcohols. Title compounds have been synthesized as shown in Scheme I. Although several commercially available hydrolytic enzymes have been tested, only three lipase preparations, namely pancreatin, steapsin, and Lipase Amano P, gave satisfactory results. Lipase-catalyzed hydrolyses of 3a-c (eq 1) were carried out