Microwave??assisted claisen rearrangement. Application to the synthesis of angelicin derivatives

H Valizadeh, A Shockravi

Index: Valizadeh, Hassan; Shockravi, Abbas Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 763 - 765

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Citation Number: 7

Abstract

4'-(Hydroxy, chloro, amino, acetoxy and methoxy)-methyl-4, 5'–dimethylangelicins were efficiently and rapidly synthesized via Claisen rearrangement of 4-methyl-7-[4-(hydroxy, chloro, amino, acetoxy and methoxy)-but-2-ynyloxy]-coumarins respectively under microwave irradiation. Prominent among the advantages of this new method are operational simplicity, good yields in short reaction times and easy work-up procedures employed.