Journal of fluorine chemistry

Synthesis of useful building blocks for monofluorinated compounds derived from trifluoroethene

Y Nakayama, T Kitazume, N Ishikawa

Index: Nakayama,Y.; Kitazume,T. Journal of Fluorine Chemistry, 1985 , vol. 29, p. 445

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Citation Number: 8

Abstract

Abstract A synthetic approach to monofluorinated compounds starts from the Friedel-Crafts acylhalogenation of trifluoroethene to give chlorotrifluoroketones and thence trifluorovinyl ketones. These are converted to phenylthio-adducts and thence monofluorinated α, β- unsaturated phenylthioesters, which by reduction afford β-fluoroallylic alcohols.