Achiral Ligands Dramatically Enhance Rate and Enantioselectivity in the Rh/Phosphoramidite??Catalyzed Hydrogenation of α, β??Disubstituted Unsaturated Acids

…, A Meetsma, TD Tiemersma??Wegman…

Index: Hoen, Rob; Boogers, Jeroen A. F.; Bernsmann, Heiko; Minnaard, Adriaan J.; Meetsma, Auke; Tiemersma-Wegman, Theodora D.; De Vries, Andre H. M.; De Vries, Johannes G.; Feringa, Ben L. Angewandte Chemie - International Edition, 2005 , vol. 44, # 27 p. 4209 - 4212

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Citation Number: 143

Abstract

In 2000, three research groups demonstrated that the widely held view that chiral bidentate ligands are necessary to achieve high enantioselectivity in rhodium-catalyzed hydrogenations needs revision. Monodentate phosphonites,[1a] phosphites [1b] and phosphoramidites [1c] proved to be highly versatile ligands for this important transformation and afforded excellent enantioselectivities for a broad range of substrates.