… . Synthesis, radioreceptor binding, and striatal adenylate cyclase stimulation of 2, 10, 11-trihydroxyaporphines in comparison with other hydroxylated aporphines

…, JS Lamont, NS Kula, RJ Baldessarini

Index: Neumeyer, John L.; Arana, George W.; Law, Say-Jong; Lamont, Jeffrey S.; Kula, Nora S.; Baldessarini, Ross J. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1440 - 1445

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Citation Number: 32

Abstract

The presence of the A ring of aporphines and the addition of substituents to it and to other portions of the aporphine ring systems can extend explorations of the dimensions and other characteristics of the dopamine receptor. Accordingly, the synthesis and some physical and pharmacological properties of a series of (-)-2, 10, 11-trihydroxyaporphines (3a-g) are described. Structureactivity relationships among mono-, di-, and trihydroxyaporphines ...