Facile Regioselective Synthesis of Pyrazolo [5, 1-a] isoquinolines via Ring-Opening Cyclization/Oxidation Reactions of Stable Aroyldiaziridines of 3, 4- …

H Ortega, S Ahmed, H Alper

Index: Ortega, Heriberto; Ahmed, Sara; Alper, Howard Synthesis, 2007 , # 23 p. 3683 - 3691

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Citation Number: 6

Abstract

Abstract Newly prepared, stable aroyldiaziridines of 3, 4-tetrahydroisoquinolines undergo regioselective cycloaddition reactions with a number of both mono and disubstituted alkynes, affording five-membered ring products which, after oxidative aromatization of the pyrazoline ring, lead to the efficient preparation of pyrazolo [5, 1-a] isoquinolines. The overall transformation is base-catalyzed and occurs more rapidly in the presence of ...