Ring A building blocks for taxoids and taxamycins

MW Tjepkema, PD Wilson, H Audrain…

Index: Tjepkema, Michael W.; Wilson, Peter D.; Audrain, Helene; Fallis, Alex G. Canadian Journal of Chemistry, 1997 , vol. 75, # 9 p. 1215 - 1224

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Citation Number: 16

Abstract

The syntheses of a series of oxygenated cyclohexene ring A synthohs 20, 22-27, 34, 36, and 37 that possess suitable functionality for further elaboration for taxoid synthesis are described. These compounds have been prepared from β-ionone by a series of oxidative and addition reactions or alternatively by Lewis acid catalyzed Diels-Alder cycloadditions with the oxygen-containing trimethyl substituted dienes 31 and 33. Key words: taxoid, ...