Macrophomate synthase: unusual enzyme catalyzing multiple reactions from pyrones to benzoates

H Oikawa, K Watanabe, K Yagi, S Ohashi, T Mie…

Index: Oikawa, Hideaki; Watanabe, Kenji; Yagi, Kenji; Ohashi, Satoshi; Mie, Takashi; Ichihara, Akitami; Honma, Mamoru Tetrahedron Letters, 1999 , vol. 40, # 38 p. 6983 - 6986

Full Text: HTML

Citation Number: 32

Abstract

Macrophomate synthase which catalyzes unusual multiple reactions from 2-pyrone (3) to macrophomic acid (1) has been purified in a homogenous state. The macrophomate synthase is a dimeric enzyme which requires Mg2+ as a co-factor and whose molecular mass is 40 kDa. Study on substrate specificity showed that the enzyme is capable of converting various 2-pyrones to the corresponding benzoates.