Tetrahedron

Platinum (II) complex-catalyzed enantioselective aldol reaction with ketene silyl acetals in DMF at room temperature

S Kiyooka, S Matsumoto, T Shibata, K Shinozaki

Index: Kiyooka, Syun-ichi; Matsumoto, Satoshi; Shibata, Tomonori; Shinozaki, Kei-ichi Tetrahedron, 2010 , vol. 66, # 10 p. 1806 - 1816

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Citation Number: 10

Abstract

[{(R)-binap} Pt (μ-OH)] 22X is a weak Lewis acid, which can catalyze the enantioselective aldol reaction of aldehydes with ketene silyl acetals in DMF at room temperature. The platinum (II) complex-catalyzed the enantioselective aldol reaction of aldehydes with 1- methoxy-2-methyl-(1-trimethylsilyloxy) propene gave the corresponding aldols in high yields with enantioselectivity up to 92%. With 5mol% loading of the complexes, the ...