Rationally designed 'dipeptoid'analogues of cholecystokinin (CCK): N-terminal structure-affinity relationships of α-methyl-tryptophan derivatives

…, JC Hunter, K Martin, MC Pritchard, SS Rahman…

Index: Eden; Higginbottom; Hill; Horwell; Hunter; Martin; Pritchard; Rahman; Richardson; Roberts European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 37 - 45

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Citation Number: 14

Abstract

Abstract The structure-affinity relationships (SAR) between the N-terminii of a series of α- methyl-tryptophanylphenethylamide derivatives and the cholecystokinin (CCK) B receptor are discussed. A series of compounds with the general formula RX-α-methyl- tryptophanylphenethylamide was prepared, where R is a cycloalkyl, a bicycloalkyl or a tricycloalkyl group and X is a urethane, thiourethane, amide, urea or a sulphinamide ...