Synthesis and use of the n-bromododecane-1, 12-diols as conformational probes for general anesthetic target sites

R Dickinson, EH Smith, NP Franks…

Index: Dickinson, R.; Smith, E. H.; Franks, N. P.; Lieb, W. R. Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 111 - 118

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Citation Number: 14

Abstract

The n-bromododecane-1, 12-diols with bromine on carbons 2, 3, 5, and 6, respectively, were synthesized and found to be potent general anesthetics. They were also found to be potent inhibitors of firefly luciferase, a protein model for the primary target sites underlying general anesthesia. However, their effects on lipid bilayers were small, lowering the chain-melting phase transition temperature by Iess than 1* C at their ECW concentrations for general ...